| # | Title | Artist | Label |
| 1 | BOOM BOOM POW | The Black Eyed Peas | will.i.am/Interscope |
| 2 | POKER FACE | Lady Gaga | Streamline/KonLive/Cherrytree/Interscope |
| 3 | JUST DANCE | Lady Gaga Featuring Colby O’Donis | Streamline/KonLive/Cherrytree/Interscope |
| 4 | I GOTTA FEELING | The Black Eyed Peas | Interscope |
| 5 | LOVE STORY | Taylor Swift | Big Machine/Universal Republic |
| 6 | RIGHT ROUND | Flo Rida | Poe Boy/Atlantic |
| 7 | I’M YOURS | Jason Mraz | Atlantic/RRP |
| 8 | SINGLE LADIES (PUT A RING ON IT) | Beyonce | Music World/Columbia |
| 9 | HEARTLESS | Kanye West | Roc-A-Fella/Def Jam/IDJMG |
| 10 | GIVES YOU HELL | The All-American Rejects | Doghouse/DGC/Interscope |
| 11 | YOU BELONG WITH ME | Taylor Swift | Big Machine/Universal Republic |
| 12 | DEAD AND GONE | T.I. Featuring Justin Timberlake | Grand Hustle/Atlantic |
| 13 | YOU FOUND ME | The Fray | Epic |
| 14 | USE SOMEBODY | Kings Of Leon | RCA/RMG |
| 15 | KNOCK YOU DOWN | Keri Hilson Featuring Kanye West & Ne-Yo | Mosley/Zone 4/Interscope |
| 16 | BLAME IT | Jamie Foxx Featuring T-Pain | J/RMG |
| 17 | I KNOW YOU WANT ME (CALLE OCHO) | Pitbull | Ultra |
| 18 | LIVE YOUR LIFE | T.I. Featuring Rihanna | Def Jam/Grand Hustle/IDJMG/Atlantic |
| 19 | KISS ME THRU THE PHONE | Soulja Boy Tell ‘em Featuring Sammie | ColliPark/Interscope |
| 20 | DOWN | Jay Sean Featuring Lil Wayne | Cash Money/Universal Republic |
| 21 | THE CLIMB | Miley Cyrus | Walt Disney/Hollywood |
| 22 | BEST I EVER HAD | Drake | Young Money/Cash Money/Universal Motown |
| 23 | MY LIFE WOULD SUCK WITHOUT YOU | Kelly Clarkson | 19/RCA/RMG |
| 24 | HALO | Beyonce | Music World/Columbia |
| 25 | HOT N COLD | Katy Perry | Capitol |
| 26 | SECOND CHANCE | Shinedown | Atlantic |
| 27 | CIRCUS | Britney Spears | Jive/JLG |
| 28 | DAY ‘N’ NITE | Kid Cudi | Fool’s Gold/G.O.O.D./Universal Motown |
| 29 | PARTY IN THE U.S.A. | Miley Cyrus | Hollywood |
| 30 | DON’T TRUST ME | 3OH!3 | Photo Finish/Atlantic/RRP |
| 31 | RUN THIS TOWN | Jay-Z, Rihanna & Kanye West | Roc Nation |
| 32 | LET IT ROCK | Kevin Rudolf Featuring Lil Wayne | Cash Money/Universal Republic |
| 33 | FIRE BURNING | Sean Kingston | Beluga Heights/Epic |
| 34 | WHATCHA SAY | Jason DeRulo | Beluga Heights/Warner Bros. |
| 35 | LOVEGAME | Lady Gaga | Streamline/KonLive/Cherrytree/Interscope |
| 36 | WAKING UP IN VEGAS | Katy Perry | Capitol |
| 37 | BIRTHDAY SEX | Jeremih | Mick Schultz/Def Jam/IDJMG |
| 38 | SOBER | Pink | LaFace/JLG |
| 39 | WOMANIZER | Britney Spears | Jive/JLG |
| 40 | WHATEVER YOU LIKE | T.I. | Grand Hustle/Atlantic |
| 41 | OBSESSED | Mariah Carey | Island/IDJMG |
| 42 | MAD | Ne-Yo | Def Jam/IDJMG |
| 43 | GOOD GIRLS GO BAD | Cobra Starship Featuring Leighton Meester | Decaydance/Fueled By Ramen/Atlantic/RRP |
| 44 | LOVE LOCKDOWN | Kanye West | Roc-A-Fella/Def Jam/IDJMG |
| 45 | SO WHAT | Pink | LaFace/JLG |
| 46 | HOTEL ROOM SERVICE | Pitbull | Mr. 305/Polo Grounds/J/RMG |
| 47 | CRACK A BOTTLE | Eminem, Dr. Dre & 50 Cent | Shady/Aftermath/Interscope |
| 48 | IF I WERE A BOY | Beyonce | Music World/Columbia |
| 49 | TURNIN ME ON | Keri Hilson Featuring Lil Wayne | Mosley/Zone 4/Interscope |
| 50 | I HATE THIS PART | The Pussycat Dolls | Interscope |
| 51 | GOTTA BE SOMEBODY | Nickelback | Roadrunner/RRP |
| 52 | PLEASE DON’T LEAVE ME | Pink | LaFace/JLG |
| 53 | PAPARAZZI | Lady Gaga | Streamline/KonLive/Cherrytree/Interscope |
| 54 | BEAUTIFUL | Akon Featuring Colby O’Donis & Kardinal Offishall | Konvict/Upfront/SRC/Universal Motown |
| 55 | VIVA LA VIDA | Coldplay | Capitol |
| 56 | RIGHT NOW (NA NA NA) | Akon | Konvict/Upfront/SRC/Universal Motown |
| 57 | BATTLEFIELD | Jordin Sparks | 19/Jive/JLG |
| 58 | SUGAR | Flo Rida Featuring Wynter | Poe Boy/Atlantic |
| 59 | MISS INDEPENDENT | Ne-Yo | Def Jam/IDJMG |
| 60 | FIREFLIES | Owl City | Universal Republic |
| 61 | NEW DIVIDE | Linkin Park | Machine Shop/Warner Bros. |
| 62 | EMPIRE STATE OF MIND | Jay-Z + Alicia Keys | Roc Nation |
| 63 | NO SURPRISE | Daughtry | 19/RCA/RMG |
| 64 | SHE WOLF | Shakira | Sony Music Latin/Epic |
| 65 | BREAK UP | Mario Featuring Gucci Mane & Sean Garrett | J/RMG |
| 66 | SWEET DREAMS | Beyonce | Music World/Columbia |
| 67 | EVERY GIRL | Young Money | Young Money/Cash Money/Universal Motown |
| 68 | FALLIN’ FOR YOU | Colbie Caillat | Universal Republic |
| 69 | UNTOUCHED | The Veronicas | EngineRoom/Sire/Warner Bros. |
| 70 | IF TODAY WAS YOUR LAST DAY | Nickelback | Roadrunner/RRP |
| 71 | THROW IT IN THE BAG | Fabolous Featuring The-Dream | Desert Storm/Def Jam/IDJMG |
| 72 | LOVE DRUNK | Boys Like Girls | Columbia |
| 73 | I LOVE COLLEGE | Asher Roth | SchoolBoy/Loud/SRC/Universal Motown |
| 74 | IF U SEEK AMY | Britney Spears | Jive/JLG |
| 75 | BIG GREEN TRACTOR | Jason Aldean | Broken Bow |
| 76 | WHITE HORSE | Taylor Swift | Big Machine |
| 77 | DISTURBIA | Rihanna | SRP/Def Jam/IDJMG |
| 78 | 21 GUNS | Green Day | Reprise |
| 79 | TURN MY SWAG ON | Soulja Boy Tell’em | ColliPark/Interscope |
| 80 | ROCKIN’ THAT THANG | The-Dream | Radio Killa/Def Jam/IDJMG |
| 81 | CHICKEN FRIED | Zac Brown Band | Home Grown/Atlantic/Bigger Picture |
| 82 | DIVA | Beyonce | Music World/Columbia |
| 83 | REPLAY | Iyaz | Time Is Money/Beluga Heights/Reprise |
| 84 | THEN | Brad Paisley | Arista Nashville |
| 85 | HER DIAMONDS | Rob Thomas | Emblem/Atlantic |
| 86 | HOW DO YOU SLEEP? | Jesse McCartney Featuring Ludacris | Hollywood |
| 87 | 3 | Britney Spears | Jive/JLG |
| 88 | FOREVER | Drake Featuring Kanye West, Lil Wayne & Eminem | Harvey Mason/Zone 4/Streamline/Interscope |
| 89 | ONE TIME | Justin Bieber | Island/IDJMG |
| 90 | I RUN TO YOU | Lady Antebellum | Capitol Nashville |
| 91 | I DO NOT HOOK UP | Kelly Clarkson | 19/RCA/RMG |
| 92 | GREEN LIGHT | John Legend Featuring Andre 3000 | G.O.O.D./Columbia |
| 93 | PEOPLE ARE CRAZY | Billy Currington | Mercury Nashville |
| 94 | WHATEVER IT IS | Zac Brown Band | Home Grown/Atlantic/Bigger Picture |
| 95 | ALREADY GONE | Kelly Clarkson | 19/RCA/RMG |
| 96 | GOODBYE | Kristinia DeBarge | SodaPop/Island/IDJMG |
| 97 | SAY HEY (I LOVE YOU) | Michael Franti & Spearhead Featuring Cherine Anderson | Boo Boo Wax/Anti-/Universal Republic |
| 98 | POP CHAMPAGNE | Jim Jones & Ron Browz Featuring Juelz Santana | Ether Boy/Universal Motown/Columbia/E1 |
| 99 | PRETTY WINGS | Maxwell | Columbia |
| 100 | NEVER SAY NEVER | The Fray | Epic |
